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Transforming growth factor-β (TGF-β) constitutes an obligate cue for both lineages, instigating the activation of SMAD3/4 heterotrimeric transcriptional assemblies to promote T-reg commitment via Foxp3 expression, whereas the concomitant presence of IL-6 or IL-21 engages STAT3, which interacts with SMAD3 in a manner that obstructs SMAD3/4 complex assembly, thereby biassing differentiation toward the Th17 lineage via induction of RORγt expression [155,156]

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Glutathione injection vs IV -both can support antioxidant levels