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Finally, since thinning of the total retinal nerve fiber layer (RNFL) due to axonal loss is a marker of neurodegeneration, the RNFL thickness assessed by optical coherence tomography (OCT) was investigated in WD patients, and a decrease in RNFL and macular thickness were appreciated in patients with neurological signs, who showed worse OCT parameters [21]

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Median pain crises were 3.0 with glutamine versus 4.0 with placebo (p = 0.005) and median hospitalisations 2.0 versus 3.0 (p = 0.005)