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Wang et al., 2012), and increased TrxR1 production or activity provides chemotherapeutic resistance to treatments that rely on the production of ROS to kill cells (Roh et al., 2017)

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Subsequent studies showed that some, but not all, preparations of recombinant protein could utilize GSH as a reductant of oxidized Prdx6 (6, 17), but this has been variable (52, 72)