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doi: 10.1101/gad.11.15.1974

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Treatment of Clozapine-Resistant Patients A meta-analysis that pooled 7546 TRS patients from 77 trials with an overall response rate of 41%, with the highest baseline positive-symptom burden as the only patient variable that significantly predicted response, demonstrates that easily measurable baseline variables—age, sex, illness duration, and cognition—do not separate responders from non-responders