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Interestingly, an impaired Fe-S cluster assembly that resulted in heme biosynthesis was observed in a human sideroblastic-like microcytic anemia in a patient with reduced GRX5 levels, thereby reinforcing the idea that thioredoxin superfamily proteins are relevant in Fe-S biosynthesis and homeostasis [30]

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[DOI] [PubMed] [Google Scholar] 3.Jaggers JR, et al