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In the context of CKD, progressive deterioration of renal function results in substantial systemic accumulation of uremic toxins, such as indoxyl sulphate, p-cresyl sulphate and trimethylamine N-oxide [142,143], which are predominantly derived from gut microbial metabolism

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Standard airplane cabin temperatures remain within acceptable ranges for Zepbound's room temperature storage allowance, but additional precautions help ensure medication integrity