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In addition to its current applications in wound healing, infection control, and modulation of inflammation, further exploration of HA in diabetes mellitus could focus on its potential to regulate systemic metabolic dysfunction, including improving insulin sensitivity, protecting pancreatic β-cells from oxidative stress, and modulating adipose tissue inflammation to alleviate insulin resistance

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The GPX4 pathway influences DCs survival, and ferroptotic stress may compromise T-cell activation, affecting immune tolerance (91, 96)