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IGF-1 is so crucial to human development that studies performed on pubertal children found that high levels of serum IGF-1 were directly correlated to higher bone mineral acquisition later on in life [14, 15]

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Senolytic drugs such as the BCL2 family inhibitors ABT-263 and ABT-737 23,24,34 selectively killed senescent IMR90 ER:RAS cells when compared with non-senescent controls (Extended Data Fig

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