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Topical Anti-Androgen Strategies Spironolactone 5 % / Niacinamide 2 % Cream (± Tretinoin 0.025 %) Peripheral androgen blockade plus barrier support

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10.3 Considerations for clinical trial design The design of clinical trials for tinnitus interventions necessitates a critical evaluation of outcome measures and study duration to accurately capture therapeutic efficacy, particularly when evaluating strategies derived from neurodegenerative disease research