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Importantly, REDEFINE 1 also showed that a significant proportion of participants achieved ≥25% body weight reduction — a threshold that, in clinical terms, represents the kind of weight loss previously achievable only through bariatric surgery

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Tumor Necrosis Factor-α Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine that is produced mainly by activated T cells and macrophages

limiting factor of the coupled reactions.