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Propionate is metabolized by hepatocytes and has been shown to increase insulin sensitivity and attenuate the lipogenic pathway, thus lowering liver triglyceride levels (Weitkunat et al., 2016)

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The endogenous activation of the Nrf2-ARE system during the development of pathology in the SOD1 G93A mouse model of ALS showed that the early Nrf2-ARE activation occurs in muscle tissue and that eventually, it progresses in a retrograde manner leading to MN loss [58], as previously described