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Earlier work demonstrated that BM cells from MM aspirates express CD38, CD203a, CD73, and CD26, with malignant plasma cells characterized by high CD38 expression and variable CD203a positivity, whereas CD73 is largely restricted to stromal and osteogenic cells (45)

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VEGF Pathway and Retinal Angiogenesis Pathological ocular angiogenesis — the basis of proliferative diabetic retinopathy (PDR), wet age-related macular degeneration (AMD), and retinopathy of prematurity (ROP) — is predominantly driven by VEGF-A overexpression in response to tissue hypoxia, oxidative stress, and advanced glycation end-product (AGE) accumulation