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Notably, magnesium ions inhibit endothelial ferroptosis and delay atherosclerosis by activating the mitogen-activated protein kinase signaling pathway, upregulating solute carrier family 7 member 11 and glutamate-cysteine ligase expression, while downregulating acyl-CoA synthetase long-chain family member 4 ( In summary, apoptosis, pyroptosis, and ferroptosis play pivotal roles in the initiation and development of atherosclerosis through their distinct molecular pathways

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Protein expression levels were quantified using Western blot analysis