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Results Fragment-based drug design and chemistry Utilizing “actives” identified in a quantitative high-throughput screen against Schistosoma mansoni TGR 20,35 , 92 commercially available low molecular weight (MW) compounds/fragments were tested by X-ray crystallography 33,34,36

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The involvement of HSP70 has recently been confirmed through photo crosslinking experiments showing a direct interaction between HSC70 and KFERQ-like motifs, enabling CMA (Seike et al., 2024)

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