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In HNSCC, the acquisition of stem-like characteristics has been strongly correlated with the upregulation of markers such as SOX2, Bmi-1, CD44, Nanog, and aldehyde dehydrogenase

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Starting on day 5, mice were treated every other day with 0.2% DNFB solution, while HG, BHG, and Dex administrations were initiated concurrently and administered once daily for two consecutive weeks