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Amyloid hypothesis The accumulation of Aβ is a hallmark pathological feature in both extensively studied autosomal dominant AD and sporadic late-onset AD patients

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used quantitative reverse transcription Quantitative Real-time polymerase chain reaction (QRT-PCR) to identify differentially regulated gene expression of islet amyloid, which is associated with islet physiology and pathology of type II diabetes mellitus, and found that it contains steroidogenic acute regulatory protein (STAR protein), which is part of the synthetic response group of steroid hormone metabolism