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However, when administered acutely at 15 mg/kg there was an increase in TBARS levels in both the striatum (by over 150%) and prefrontal cortex (by over 300%) and when given at 10 mg/kg there was an increase in SOD activity in the prefrontal cortex (by over 40%)

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Notably, both the studies by Keefe and Cistulli were unblinded and lacked a control group

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