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References Primary sources for this guide: PMID 39161060 (Diabetes, Obesity and Metabolism, 2024) for the mouse pharmacokinetics by intravenous, subcutaneous and oral routes, the 3.5% oral bioavailability, the 78 ng/mL mouse NNMT IC50, the hepatocyte stability data and the 28–30 day efficacy study

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Clinical trials have shown that topical application can improve skin density, reduce fine lines, enhance clarity, and increase overall skin thickness