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Their strong hydrophilicity limits membrane partitioning, while ionizable side chains often interact unfavorably with the mucosal surface, making passive diffusion largely ineffective

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This is in line with what was previously reported ( In order to determine whether circulating Daratumumab in the combination therapy patient is functional, we performed an in vitro complement dependent cytotoxicity (CDC) assay with NK92 target cells ( Supplementary Figure 4B )