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In a 5-day phase 1 MAD trial where four groups of healthy volunteers received twice-daily or thrice-daily doses of GLY-200, decreases in glucose and insulin, along with increases in bile acids, GLP-1, peptide YY, and glicentin are noted in the cohorts with twice-daily dosing versus those receiving placebo (150)

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[DOI] [PubMed] [Google Scholar] 95.Seddio AE, Gouzoulis MJ, Vasudevan RS, Dhodapkar MM, Jabbouri SS, Varthi AG, Rubio DR, Grauer JN