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Polyunsaturated fatty acids Polyunsaturated fatty acids (PUFAs) have at least two carbon–carbon double bonds in their carboxylic chains

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396 , 401 Intestinal barrier and systemic inflammation Increased permeability of intestinal mucosa Dysbiosis of the intestinal microbiota can significantly increase intestinal mucosal permeability by down-regulating the expression of tight junction proteins (occludin, ZO-1), thereby promoting the entry of LPS and bacterial metabolites into the systemic circulation and activating systemic inflammatory responses