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In combination with bupropion, naltrexone, a µ-opioid receptor antagonist, acts in a synergistic manner to stimulate weight loss by blocking the β-endorphin-mediated inhibition of the POMC neuron [192]

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To convert: Molar concentration (µM) = [mg/mL × 1000] / Molecular weight (g/mol) Example: - Stock concentration: 1 mg/mL AOD-9604 (MW = 1817.12 g/mol) - Molar concentration: (1 × 1000) / 1817.12 = 0.55 mM = 550 µM Step 4: Add Solvent to the Vial Using a sterile syringe, draw up the calculated volume of reconstitution solvent