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📖 Read the full open-access paper here: CRBS - Centre de recherche en biomédecine de Strasbourg Université de Strasbourg #ScienceReview #Metabolism #BariatricSurgery #AMPK #ObesityResearch To view or add a comment, sign in “Successful management of knee osteoarthritis depends on identifying the dominant phenotype and targeting treatment at the primary pain generator—alignment, inflammation, metabolism, bone, or cartilage.” Metabolic / Obesity-Related Phenotype:----- Pathology:---- Systemic low-grade inflammation Adipokine-mediated cartilage degradation Clinical clues:----- Obesity Bilateral disease Rapid progression Treatment:---- Weight loss (most effective intervention) Exercise therapy Metabolic risk factor optimisation Analgesia Arthroplasty when indicated Inflammatory / Synovitis-Dominant Phenotype:-------- Pathology:-------- Synovial inflammation Effusions Pain disproportionate to X-ray changes Clinical clues:-------- Night pain Swelling, warmth Pain at rest Imaging:----------- MRI: synovitis, effusion, bone marrow oedema Treatment:---------- NSAIDs Intra-articular corticosteroid injections Short-term disease-modifying strategies Consider PRP (selected cases) 📌 Avoid early surgery unless inflammation controlled To view or add a comment, sign in 🦴 Osteoarthritis & Osteoporosis: What ACTUALLY Works (Beyond Painkillers) After years of treating patients with osteoarthritis and osteoporosis, one truth becomes very clear: 👉 No single modality works in isolation

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Contains:1 sterile vial x 238 mg/0.0084 oz. vials.

doi.org/10.1016/j.molmet.2022.101533 Drucker, D