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In non-small cell lung cancer, APOC2 K70 lactylation is substantially upregulated in patients resistant to immunotherapy and is negatively linked to overall survival in both non-small cell lung cancer and gastric cancer ( + T cell frequency ( + IFN-γ + and CD69 + CD8 + T cells in the tumor microenvironment, conferring immunotherapeutic resistance ( 6.4 Targeted therapy resistance In lenvatinib-resistant hepatocellular carcinoma, proteomic analysis showed elevated lactylation modifications, especially IGF2BP3 K76la, which enhances serine metabolism reprogramming and m6A modification, improving antioxidant ability and lenvatinib resistance ( It is important to note that current lactylation research faces several methodological limitations

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