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Adipose tissue biology research has particularly benefited from the availability of research-grade retatrutide, as the simultaneous GLP-1R and GCGR activation enables researchers to study distinct pathways of adipocyte lipolysis regulation that were previously difficult to separate experimentally

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The foundational work isolating the fragment’s fat-metabolizing activity came out of Frank Ng’s laboratory at Monash University, part of a broader research program into which regions of the GH molecule could be separated from its growth-promoting effects