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Methylation levels of NLRP3, TGFβ1, MCP-1, and TNFSF2 are significantly lower in DR patients compared to healthy individuals, suggesting that hypomethylation of these genes contributes to DR progression [66]

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Abnormal iron deposits are found in ALS patients, and iron deposits were found in the motor cortex of the patient's brain at autopsy (Kwan et al., 2012)