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Thus were the conclusions made in a 2015 paper published in Cell Metabolism , in which the authors noted that MOTS-c has “physiological similarities to the first-line diabetes drug metformin” with regard to managing glucose utilization, metabolism, and body weight.18 Reduced body fat Considering the effects that MOTS-c has on insulin response and glucose uptake — two factors associated with weight gain — the authors of the 2015 paper referenced above also examined the peptide’s potential for preventing obesity.19 Specifically, in a group of mice fed a high-fat diet, MOTS-c appeared to prevent obesity onset.18 Other studies have corroborated these results by finding that higher plasma MOTS-c levels are negatively correlated with obesity.20 Improved physical performance Recall that endogenous MOTS-c can be activated by exercise, allowing your skeletal muscles to use glucose for energy to meet their high energy demand

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