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Specifically, cytoplasmic DNA is recognized by the DNA-binding protein cyclic GMP–AMP synthase (cGAS), which facilitates cGAS homodimerization and the production of the second messenger cyclic GMP–AMP (cGAMP)

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Furthermore, H&E-stained slices were used to assess acute tubular injury in a blinded way, including tubular epithelial vacuolization, dilation of tubular lumen, brush border loss, or cast formation

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