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Indeed, synergy between levodopa and natural bioactives already has clinical precedent: istradefylline, modeled after caffeine's natural adenosine A 2 A antagonism, is used to reduce levodopa's “off” periods, while green tea's (+)‐catechin demonstrates COMT inhibition, potentially enhancing levodopa's duration of effect [4, 116, 118]

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These GI side effects tend to be most pronounced during the first 2 to 4 weeks and during dose escalation periods