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SAM is also involved in the regulation of tau phosphorylation.51 Moreover, hyperhomocysteinaemia has been shown to be associated with a significant increase in amyloid level and amyloid deposition on cortex and hippocampus in mouse models of AD.53 Overall, vitamin B 12 deficiency may have implications in the neuropathological process of AD

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As you age, your body makes less stomach acid and a type of protein called intrinsic factor