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Around exercise, high-dose peri-workout antioxidants attenuate hormetic training adaptations, including mitochondrial biogenesis and improvements in insulin sensitivity
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Within the cytosol of cells, glutathione is kept primarily in the reduced GSH form, largely by reduction of GSSG by the enzyme glutathione reductase, at the expense of NADPH: The mechanism of this reaction is complex, as the enzyme contains a pair of cysteine residues that reversibly form a disulfide bond, plus one FAD molecule (3)