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However, because of the high IAP level in the small intestine, oral IAP supplementation is insufficient to significantly increase the IAP level in the lumen

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In prostate cancer, expression of androgen receptor–mediated LAT3 ( SLC43A1 ) and leucine uptake can be inhibited by anti-androgen treatment, inducing the compensatory upregulation of LAT1 ( SLC7A5 ) (Wang et al., 2011)