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The KRAS (G12C)-mediated phenotypic transformation of T cells has been shown to be a consequence of the secretion of IL-10 and TGF-β1 mediated by MEK/ERK/AP-1 signalling in CRC 106

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The increase in IFN-γ production by CD4 + ( Figure 5H ) and CD8 + T cells ( Figure 5I ) in the TME were not detected in cells from MyD88 -/- animals

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