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Abbreviations 12-LOX 12-lipoxygenase ATF6 activating transcription factor 6 CHOP C/EBP-homologous protein DHPS deoxyhypusine synthase ER endoplasmic reticulum GCN2 general control nonderepressible 2 GPX glutathione peroxidase GST glutathione-S-transferase HRI heme-regulated inhibitor IRE1α inositol requiring enzyme1α ISR integrated stress response JNK c-Jun N-terminal kinase Keap1 Kelch-like ECH-associated protein 1 LC3 light chain 3 mRNA messenger RNA mTORC1 mammalian target of rapamycin complex 1 NF-κB nuclear factor-κB NOD nonobese diabetic NQ-O1 NAD(P)G: quinone oxidoreductase 1 NRF2 nuclear factor-erythroid factor 2-related factor 2 PERK PKR-like endoplasmic reticulum kinase PKR protein kinase R ROS reactive oxygen species SOD superoxide dismutase STAT signal transducer and activator of transcription STZ streptozotocin T1D type 1 diabetes T2D type 2 diabetes tRNA transfer RNA TUDCA tauroursodeoxycholic acid TXNIP thioredoxin interacting protein UPR unfolded protein response XBP1 X-box-binding protein 1 Contributor Information Abhishek Kulkarni, Kovler Diabetes Center and Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
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