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10.1038/s41583-021-00533-w [DOI] [PMC free article] [PubMed] [Google Scholar] Fulop T., Tripathi S., Rodrigues S., Desroches M., Bunt T., Eiser A., et al

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IPA was used to identify the upstream regulators that explained the observed changes in the metabolites because upstream regulators were activated early and subsequently contributed to downstream metabolic changes (Figure 5