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Higher levels of CTLA4 are associated with an increased risk of T cell exhaustion and worse cancer prognosis.[ref] Lower levels of CTLA4 are associated with an increased risk of some autoimmune diseases, although it isn’t always straightforward.[ref][ref] LAG-3 (Lymphocyte-activation gene 3): LAG-3 is a cell surface receptor on T cells that regulates T cell response, acting as a brake or checkpoint

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Aldehyde dehydrogenases (ALDHs) metabolize electrophilic aldehydes