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But on the other hand, NADPH supports ROS production via NOX2 and thereby, increased PPP and NADPH contribute to triggering ROS-dependent pro-inflammatory signaling cascades such as NF-κB and MAPK (Dionisio et al., 2023)

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Food & Drug Administration (FDA) would disagree with DSIP’s designation as “incredibly safe,” as the peptide is included on its list of bulk drug substances with significant safety risks