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6.1 Neurodegenerative diseases Aging is one of the main risk factors for neurodegenerative diseases, promoting their onset and progression through reduced hippocampal neurogenesis, loss of synaptic plasticity, and inflammaging (Kritsilis et al., 2018

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HMC3 cells can also be successfully maintained in alternative media, including MEM or DMEM/F12 supplemented with 10% serum, which provide enhanced pH stability, support more rapid proliferation, and preserve typical microglial morphology (162)