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Studies have shown that ACh and nicotine can suppress the release of TNF-α in LPS-induced human macrophages, and vagus nerve stimulation can also suppress LPS-induced TNF-α synthesis in wild-type mice

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2.1 The Role of Ferroptosis in Atherosclerosis AS is a chronic progressive vascular disease characterized by disturbances in lipid metabolism (Weber and Noels 2011) and narrowing of the arterial lumen through the formation of atherosclerotic plaques in the arterial wall (Veseli et al., 2017