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These events trigger downstream signaling pathways, including AKT, Ras (rat sarcoma), and STAT3 pathways, which are required for MET biological activities (Ponzetto et al., 1994

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Oxidative stress is controlled very tightly in the thyroid gland via the synthesis of glutathione peroxidase, which can safely inactivate sources of oxidative stress, such as hydrogen peroxide and free radicals