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Second, disease stage may affect the direction of mitochondrial dynamics: in early stress states, mitochondrial fusion or moderate mitophagy may serve a compensatory role, whereas in long-term injury or advanced disease, enhanced fission, cristae structural damage, and energy depletion may be more prominent (62)

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TB-500 administered from an unverified research-grade source carries real risks: unknown concentration, unverified sterility, and no quality control documentation