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Results from the largest and most recent meta-analysis of 38 clinical trials showed that regular ingestion of green tea significantly reduced markers of oxidative stress, including MDA, TAC, and increased the activities of two antioxidant enzymes, SOD and GPX, that metabolize ROS [67]

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however, VEGFR-2 has been known to be activated independent of its ligand ( VEGFR-2 Considered one of the key components of endothelial proliferation and vascular growth, VEGFR-2, also known as fetal liver kinase 1 (Flk-1) or kinase insert domain receptor (KDR), is mostly found within vascular ECs, though it is also weakly expressed in other cells such as osteoblasts, hematopoietic cells, and megakaryocytes (30, 31)