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Serial assessments included clinical laboratory measures, efficacy measures, and biomarkers associated with neuroprotection and remyelination to assess the therapeutic potential of CNM-Au8 were accomplished ( 8 Potential toxicological risks and immunogenicity associated with nanoparticles Physicochemical properties of the NPs provide significant advantages in a wide range of fields, particularly in medicine and industry (189) owing to their compact size, huge surface area, and substantial surface reactivity (190)