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Fibrosis extends into the enteric nervous system, where ischemia and inflammation lead to neuronal loss and reactive gliosis within the myenteric plexus, impairing communication between smooth muscle and intrinsic neural circuits [12]

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These chronic active MS lesions may also harbor at their core (but not at their expanding edges) a perivascular cuff of CNS tissue-resident B and T cells (Machado-Santos et al., 2018