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Metformin, a first-line biguanide, reduces hepatic glucose production, while tirzepatide—a dual GIP/GLP-1 receptor agonist approved by the FDA in 2022—enhances insulin secretion, suppresses glucagon, and promotes weight loss

1000 mcg ml

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Bioengineered skins may be produced as cellular grafts (biomaterials seeded with the skin cells) or acellular grafts (biomaterial without the cells) [136,140]

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