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In addition, probiotics can exert systemic effects through the gut–brain–skin axis, influencing skin health and wound healing processes

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This work revealed that the mean number of DUs per patient was significantly lower in the sildenafil group than the placebo group at weeks 8 (1.23±1.61 vs 1.79±2.40, P =0.04) and 12 (0.86±1.62 vs 1.51±2.68, P =0.01), resulting from a greater healing rate in the sildenafil group ( P =0.01 at week 8 and P =0.03 at week 12)