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Causes of Glutathione Deficiency Normally glutathione is recycled in the body but a variety of all-too-common reasons can deplete or offset your body's glutathione levels and trigger oxidative stress including: Aging Trauma Chronic illnesses Infections Medications Stress Poor diet Pollutions Toxins When to Talk to a Provider About Glutathione Levels Significant glutathione depletion has been discussed in the medical literature in connection with certain rare genetic and metabolic conditions