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Meanwhile, osteoblasts in OA exhibit a pathological phenotype, marked by increased secretion of RANKL, VEGF, and TGF-β1, and impaired mineralization due to altered collagen synthesis

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Ursolic acid, a pentacyclic triterpenoid compound derived from traditional plants, when combined with sorafenib, has been shown to markedly enhance the accumulation of ROS in a hepatocellular model