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Why Absorption Matters: The B12 Challenge The journey of B12 from your plate to your cells involves several steps: B12 from food is bound to proteins and must be released by stomach acid It then binds to intrinsic factor, a protein produced by the stomach This complex travels to the small intestine where B12 is absorbed Finally, it enters the bloodstream for transport to cells This elaborate process explains why many people, despite adequate dietary intake, may still experience functional B12 deficiency