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In an earlier study, free radical production was lowered in hypothyroidism due to reduced metabolism induced by the decline of thyroid hormone levels (Venditti et al., 1997)

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4.4 Maternal RPM supplementation and offspring performance Considering that embryonic development is the period of extensive epigenetic reprogramming, maternal nutrition during the periconceptional and early pregnancy stages plays a crucial role in establishing the molecular and physiological foundations for fetal growth and long-term offspring performance